Identification of BRAF Kinase Domain Duplications Across Multiple Tumor Types and Response to RAF Inhibitor Therapy

JAMA Oncol. 2016 Feb;2(2):272-4. doi: 10.1001/jamaoncol.2015.4437.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antineoplastic Agents / therapeutic use*
  • Carcinoma, Acinar Cell / drug therapy*
  • Carcinoma, Acinar Cell / enzymology
  • Carcinoma, Acinar Cell / genetics
  • Carcinoma, Acinar Cell / pathology
  • DNA Mutational Analysis
  • Female
  • Gene Duplication*
  • Gene Expression Profiling
  • Humans
  • Mutation
  • Parotid Neoplasms / drug therapy*
  • Parotid Neoplasms / enzymology
  • Parotid Neoplasms / genetics
  • Parotid Neoplasms / pathology
  • Precision Medicine
  • Predictive Value of Tests
  • Protein Kinase Inhibitors / therapeutic use*
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
  • Proto-Oncogene Proteins B-raf / genetics
  • Proto-Oncogene Proteins B-raf / metabolism
  • Remission Induction
  • Treatment Outcome

Substances

  • Antineoplastic Agents
  • Protein Kinase Inhibitors
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf