Can daytime measures of lung function predict respiratory failure in children with neuromuscular disease?

C A Pandit; K Waters; K J Jones; H Young; D A Fitzgerald

doi:10.1016/j.prrv.2015.08.001

Can daytime measures of lung function predict respiratory failure in children with neuromuscular disease?

Paediatr Respir Rev. 2015 Sep;16(4):241-5. doi: 10.1016/j.prrv.2015.08.001. Epub 2015 Aug 12.

Authors

C A Pandit¹, K Waters², K J Jones³, H Young⁴, D A Fitzgerald²

Affiliations

¹ Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney. Electronic address: [email protected].
² Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney; Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney.
³ Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney; Department of Clinical Genetics, The Children's Hospital at Westmead, Sydney.
⁴ Discipline of Paediatrics and Child Health, Sydney Medical School, University of Sydney; Department of Neurology, The Children's Hospital at Westmead, Sydney.

PMID: 26563514
DOI: 10.1016/j.prrv.2015.08.001

Abstract

Neuromuscular disorders in children are a heterogeneous group of conditions with a variable age of presentation and overlapping clinical manifestations, many of which have progressive respiratory morbidity. Respiratory insufficiency occurs as a consequence of an imbalance between demands on the respiratory system and respiratory muscle capacity. Daytime measures of pulmonary function are used routinely in these children to assess respiratory status and monitor the consequences of the progression of muscle weakness. This review describes the current evidence for daytime pulmonary function tests and their ability to predict imminent respiratory morbidity.

Keywords: Daytime measures; Neuromuscular disease; Pulmonary function.

Publication types

Review

MeSH terms

Child
Humans
Neuromuscular Diseases / complications
Neuromuscular Diseases / physiopathology*
Respiratory Function Tests
Respiratory Insufficiency / etiology
Respiratory Insufficiency / physiopathology*
Respiratory Muscles / physiopathology*
Risk Assessment
Wakefulness