Natural product-derived quaternary ammonium compounds with potent antimicrobial activity

J Antibiot (Tokyo). 2016 Apr;69(4):344-7. doi: 10.1038/ja.2015.107. Epub 2015 Nov 18.

Authors

Maureen D Joyce¹, Megan C Jennings², Celina N Santiago¹, Madison H Fletcher², William M Wuest², Kevin Pc Minbiole¹

Affiliations

¹ Department of Chemistry, Villanova University, Villanova, PA, USA.
² Department of Chemistry, Temple University, Philadelphia, PA, USA.

PMID: 26577453
DOI: 10.1038/ja.2015.107

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Alkylation
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Biological Products / chemical synthesis*
Biological Products / chemistry
Biological Products / pharmacology*
Enterococcus faecalis / drug effects
Escherichia coli / drug effects
Gnetum / chemistry
Microbial Sensitivity Tests
Nicotine / chemistry*
Pseudomonas aeruginosa / drug effects
Quaternary Ammonium Compounds / chemical synthesis*
Quaternary Ammonium Compounds / chemistry
Quaternary Ammonium Compounds / pharmacology*
Quinine / chemistry*
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Biological Products
Quaternary Ammonium Compounds
Nicotine
Quinine