Prolonged and Severe Gestational Thyrotoxicosis Due to Enhanced hCG Sensitivity of a Mutant Thyrotropin Receptor

J Clin Endocrinol Metab. 2016 Jan;101(1):10-1. doi: 10.1210/jc.2015-3670. Epub 2015 Nov 18.

Abstract

Context: Gestational thyrotoxicosis, whether associated with hyperemesis gravidarum or not, is thought to be due to excessive human chorionic gonadotropin (hCG) secretion.

Case description: We report here the second case of gestational thyrotoxicosis associated with hyperemesis gravidarum due to a mutation of the TSH receptor, providing thyroid hypersensitivity to hCG.

Conclusion: Severe and lasting gestational thyrotoxicosis with normal hCG concentration should lead to sequencing of the TSH receptor gene.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Chorionic Gonadotropin*
  • Disease Progression
  • Female
  • Humans
  • Hyperemesis Gravidarum / complications
  • Mutation / genetics
  • Pregnancy
  • Pregnancy Complications / genetics*
  • Pregnancy Complications / metabolism*
  • Receptors, Thyrotropin / genetics*
  • Receptors, Thyrotropin / metabolism*
  • Thyroid Function Tests
  • Thyroid Hormones / metabolism
  • Thyrotoxicosis / genetics*
  • Thyrotoxicosis / metabolism*

Substances

  • Chorionic Gonadotropin
  • Receptors, Thyrotropin
  • Thyroid Hormones