Common Characteristics of HIV-Neutralizing Antibodies with a Fondness for Sugars

Andrew T McGuire; Leonidas Stamatatos

doi:10.1016/j.immuni.2015.10.026

Common Characteristics of HIV-Neutralizing Antibodies with a Fondness for Sugars

Immunity. 2015 Nov 17;43(5):837-40. doi: 10.1016/j.immuni.2015.10.026.

Authors

Andrew T McGuire¹, Leonidas Stamatatos²

Affiliations

¹ Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: [email protected].
² Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Department of Global Health, University of Washington, Seattle, WA 98109, USA. Electronic address: [email protected].

PMID: 26588775
DOI: 10.1016/j.immuni.2015.10.026

Abstract

Broadly neutralizing antibodies targeting quaternary epitopes on the apex of the HIV-1 envelope spike are an attractive vaccine target, yet engineering immunogens that recapitulate such epitopes has proven difficult. In this issue of Immunity, Andrabi and colleagues (2015) identify an exciting new candidate immunogen that could initiate the production of these types of antibodies through vaccination.

Publication types

Comment

MeSH terms

Antibodies, Neutralizing / immunology*
HIV Antibodies / immunology*
HIV-1 / immunology*
Humans
Vaccines / immunology*
Viral Envelope Proteins / immunology*
env Gene Products, Human Immunodeficiency Virus / immunology*

Substances

Antibodies, Neutralizing
HIV Antibodies
Vaccines
Viral Envelope Proteins
env Gene Products, Human Immunodeficiency Virus