Women's mental health is determined not only by individual factors, in which genetics and hormones play a role, but also by relational and community factors. Women of any age more frequently suffer from certain mental disorders and have more comorbidity rates. Specificities in women exist in clinical presentations, as well as in the use of psychotropic medication, the incidence of side effets and in adherence to care. The role of primary care physicians is crucial for the prevention and detection of mental disorders in women, particularly in vulnerable ones, as well as in their psychological support, organization and continuity of care. A comprehensive approach is required, which includes measures against isolation, insecurity, stigmatization and inequality.