Soil contamination by heavy metals and persistent organic pollutants tends to be severe. Pot experiment was conducted to investigate the phytoremediation of cadmium (Cd) in Cd-OCDF Co-contaminated Soil by Mirabilis jalapa L., using OCDF and Cd as the model pollutants of persistent organic pollutants and heavy metals, to study. the growth responses of plant and OCDF effects on phytoremediation of Cd. The results showed that during three months of planting the height and dry biomass of Mirabilis jalapa L. decreased slightly when the Cd concentration was not higher than 200 mg x kg(-1), and the plant exhibited high tolerance to Cd and OCDF. Compared with the Cd single pollution, OCDF had no significant effect on the height and root biomass of Mirabilis jalapa L. When the concentration of Cd was 200 mg x kg(-1) and the concentration of OCDF was 500 microg x kg(-1), the shoot biomass was reduced by 22.19%. In other treatments, OCDF showed no significant inhibition to the shoot biomass of Mirabilis jalapa L., but increased the shoot biomass in some treatments. Compared with single Cd pollution, when the concentration of Cd was 200 mg x kg(-1) and the concentration of OCDF was 100 microg x kg(-1), the Cd accumulation of root was reduced by 34.44%. When the concentration of Cd was 400 mg x kg(-1) and the concentration of OCDF was 100 microg x kg(-1), the Cd accumulation in root and leaf was reduced by 7.93% and 18.09%, respectively. In other treatments, OCDF promoted the extraction and accumulation of Cd by root, stem and leaf of Mirabilis jalapa L. from soil to some degree. So using Mirabilis jalapa L. to remediate Cd from high Cd concentration and OCDF cocontaminated soil is feasible.