1 *Department of Medicine, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina †Center for Gastrointestinal Biology, and Disease, Chapel Hill, North Carolina ‡Department of Medicine, University of North Carolina, Chapel Hill, North Carolina §Department of Pediatrics, Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina ‖Department of Dermatology, Duke University, Durham, North Carolina.