More than the genes, the tumor microenvironment in neuroblastoma

Lucia Borriello; Robert C Seeger; Shahab Asgharzadeh; Yves A DeClerck

doi:10.1016/j.canlet.2015.11.017

More than the genes, the tumor microenvironment in neuroblastoma

Cancer Lett. 2016 Sep 28;380(1):304-14. doi: 10.1016/j.canlet.2015.11.017. Epub 2015 Nov 17.

Authors

Lucia Borriello¹, Robert C Seeger¹, Shahab Asgharzadeh¹, Yves A DeClerck²

Affiliations

¹ Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
² Division of Hematology, Oncology and Blood and Marrow Transplantation, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Pediatrics, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA; The Saban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA; Department of Biochemistry and Molecular Biology, Keck School of Medicine of the University of Southern California, Los Angeles, CA, USA. Electronic address: [email protected].

Abstract

Neuroblastoma is the second most common solid tumor in children. Since the seminal discovery of the role of amplification of the MYCN oncogene in the pathogenesis of neuroblastoma in the 1980s, much focus has been on the contribution of genetic alterations in the progression of this cancer. However it is now clear that not only genetic events play a role but that the tumor microenvironment (TME) substantially contributes to the biology of neuroblastoma. In this article, we present a comprehensive review of the literature on the contribution of the TME to the ten hallmarks of cancer in neuroblastoma and discuss the mechanisms of communication between neuroblastoma cells and the TME that underlie the influence of the TME on neuroblastoma progression. We end our review by discussing how the knowledge acquired over the last two decades in this field is now leading to new clinical trials targeting the TME.

Keywords: Cell–cell communication; Hallmarks of cancer; Neuroblastoma; Tumor microenvironment.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism*
Cell Communication
Cell Movement
Cell Proliferation
Cell Survival
Disease Progression
Gene Expression Regulation, Neoplastic
Humans
Neuroblastoma / genetics
Neuroblastoma / metabolism*
Neuroblastoma / pathology
Neuroblastoma / therapy
Signal Transduction
Tumor Microenvironment*

Substances

Biomarkers, Tumor

Abstract

Publication types

MeSH terms

Substances

Grants and funding