Multidrug-resistant tuberculosis among different types of suspected cases: Study from New Delhi

Ritu Singhal; Neeta Singla; Vithal Prasad Myneedu; Niti Singh; Rohit Sarin

doi:10.1016/j.ijtb.2015.09.004

Multidrug-resistant tuberculosis among different types of suspected cases: Study from New Delhi

Indian J Tuberc. 2015 Jul;62(3):183-6. doi: 10.1016/j.ijtb.2015.09.004. Epub 2015 Nov 4.

Authors

Ritu Singhal¹, Neeta Singla², Vithal Prasad Myneedu³, Niti Singh⁴, Rohit Sarin⁵

Affiliations

¹ Specialist Microbiology, Department of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, India.
² Senior Research Officer, Department of Epidemiology, National Institute of Tuberculosis and Respiratory Diseases, India.
³ Head of Department, Department of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, India. Electronic address: [email protected].
⁴ NRL Microbiologist, Department of Microbiology, National Institute of Tuberculosis and Respiratory Diseases, India.
⁵ Director of the Institute, National Institute of Tuberculosis and Respiratory Diseases, India.

PMID: 26600333
DOI: 10.1016/j.ijtb.2015.09.004

Abstract

There are limited data of multidrug-resistant tuberculosis (MDR-TB) diagnosed in various patient categories by implementing Programmatic Management of Drug Resistant TB (PMDT) using line probe assay (LPA) from our country. Samples from presumptive MDR-TB from five districts of New Delhi were subjected to LPA from 1st October 2011 to 31st December 2014. The MDR-TB diagnosed in 4th & 5th month follow-up positives were significantly higher than other categories of the patients. Only 3/232 (2.2%) RIF resistants were diagnosed among smear negative re-treatment cases. The data suggest interim cost-benefit analysis of the program especially among smear negatives retreatment cases.

Keywords: Line probe assay; Multi-drug resistance; Mycobacterium.

MeSH terms

Humans
India / epidemiology
Tuberculosis, Multidrug-Resistant / diagnosis*
Tuberculosis, Multidrug-Resistant / epidemiology
Tuberculosis, Multidrug-Resistant / therapy