Abstract
We assessed prevalence of and risk factors for candidaemia following Clostridium difficile infection (CDI) using longitudinal population-based surveillance. Of 13 615 adults with CDI, 113 (0·8%) developed candidaemia in the 120 days following CDI. In a matched case-control analysis, severe CDI and CDI treatment with vancomycin + metronidazole were associated with development of candidaemia following CDI.
Keywords:
CDI treatment; Candidaemia; Clostridium difficile infection; co-infection; severe CDI.
MeSH terms
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Adolescent
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Adult
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Aged
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Anti-Bacterial Agents / therapeutic use*
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Candida / physiology*
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Candidemia / drug therapy
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Candidemia / epidemiology*
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Candidemia / microbiology
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Case-Control Studies
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Clostridioides difficile / physiology*
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Clostridium Infections / complications
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Clostridium Infections / drug therapy
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Clostridium Infections / epidemiology*
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Clostridium Infections / microbiology
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Female
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Georgia / epidemiology
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Humans
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Longitudinal Studies
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Male
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Metronidazole / therapeutic use*
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Middle Aged
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Prevalence
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Risk Factors
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Vancomycin / therapeutic use*
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Young Adult
Substances
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Anti-Bacterial Agents
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Metronidazole
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Vancomycin