Switching first contact: photocontrol of E. coli adhesion to human cells

Chem Commun (Camb). 2016 Jan 21;52(6):1254-7. doi: 10.1039/c5cc08884d.

Abstract

We have shown previously that carbohydrate-specific bacterial adhesion to a non-physiological surface can be photocontrolled by reversible E/Z isomerisation using azobenzene-functionalised sugars. Here, this approach is applied to the surface of human cells. We show not only that bacterial adhesion to the azobenzene glycoside-modified cell surface is higher in the E than in the Z state, but add data about the specific modulation of the effect.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Adhesion*
  • Escherichia coli / physiology*
  • Humans
  • Isomerism