Effects of perioperative blood transfusion on the prognosis in hereditary and sporadic colon cancer

Biomarkers. 2015;20(6-7):481-6. doi: 10.3109/1354750X.2015.1096306.

Abstract

We investigated the effects of perioperative blood transfusion in the prognosis of hereditary and sporadic colon cancer. There are 1075 colon cancer patients, including 936 sporadic colon cancer and 139 with hereditary colon cancer undergoing surgery at our hospital. All patients underwent 10 years of follow-up. In the sporadic group, mortality, local recurrence rate and distant metastases rate of transfused patients were significantly higher than non-transfused patients. The 10-year survival rates were significantly lower in patients receiving blood transfusions compared to non-transfused patients. In the hereditary group, mortality was higher in transfused patients compared to non-transfused patients.

Keywords: Allogeneic red blood cell transfusion; colon cancer; hereditary colon cancer; mortality; perioperative blood transfusion; prognosis survival; sporadic colon cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Blood Transfusion / methods*
  • Colonic Neoplasms / mortality
  • Colonic Neoplasms / surgery*
  • Colonic Neoplasms / therapy*
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Recurrence, Local
  • Outcome Assessment, Health Care / methods
  • Outcome Assessment, Health Care / statistics & numerical data
  • Perioperative Period*
  • Prognosis
  • Proportional Hazards Models
  • Survival Rate
  • Time Factors