Role of Endoscopy in Diagnosis and Management of Pediatric Eosinophilic Esophagitis

Gastrointest Endosc Clin N Am. 2016 Jan;26(1):187-200. doi: 10.1016/j.giec.2015.08.006.

Abstract

Eosinophilic esophagitis (EoE) is a chronic allergic (immune-mediated) disease that leads to esophageal dysfunction and feeding disorders in children. Foods, and possibly environmental triggers, cause an inflammatory response in the esophagus, leading to esophageal inflammation, eosinophilic infiltration, and esophageal dysmotility, which may progress to dysphagia, food impaction, and esophageal stricture. Endoscopy with biopsy and histologic evaluation is currently the only method to diagnose EoE. Once diagnosed with EoE, children undergo follow-up endoscopy after therapy initiation and adjustments to ensure remission. Furthermore, children with food impactions or strictures may require endoscopic intervention such as foreign body removal and/or esophageal dilation.

Keywords: Dilation; Dysphagia; Eosinophilic esophagitis; Food allergy; Food impaction.

Publication types

  • Review

MeSH terms

  • Biopsy
  • Child
  • Deglutition Disorders / etiology
  • Deglutition Disorders / surgery
  • Dilatation
  • Endoscopy, Digestive System / methods*
  • Eosinophilic Esophagitis / complications
  • Eosinophilic Esophagitis / diagnosis*
  • Eosinophilic Esophagitis / surgery*
  • Esophageal Stenosis / diagnosis
  • Esophageal Stenosis / etiology
  • Esophageal Stenosis / surgery
  • Esophagus / pathology
  • Esophagus / surgery
  • Humans