Ehrlichia's molecular tricks to manipulate their host cells

Amal Moumène; Damien F Meyer

doi:10.1016/j.micinf.2015.11.001

Ehrlichia's molecular tricks to manipulate their host cells

Microbes Infect. 2016 Mar;18(3):172-9. doi: 10.1016/j.micinf.2015.11.001. Epub 2015 Nov 23.

Authors

Amal Moumène¹, Damien F Meyer²

Affiliations

¹ CIRAD, UMR CMAEE, Site de Duclos, Prise d'eau, F-97170 Petit-Bourg, Guadeloupe, France; INRA, UMR1309 CMAEE, F-34398 Montpellier, France; Université des Antilles et de la Guyane, 97159 Pointe-à-Pitre Cedex, Guadeloupe, France.
² CIRAD, UMR CMAEE, Site de Duclos, Prise d'eau, F-97170 Petit-Bourg, Guadeloupe, France; INRA, UMR1309 CMAEE, F-34398 Montpellier, France. Electronic address: [email protected].

PMID: 26617397
DOI: 10.1016/j.micinf.2015.11.001

Abstract

Ehrlichia is a large genus of obligate intracellular Gram-negative bacteria transmitted by ticks that cause several emerging infectious diseases in humans and are pathogenic on rodents, ruminants, and dogs. Ehrlichia spp. invade and replicate either in endothelial cells, white blood cells, or within midgut cells and salivary glands of their vector ticks. In this review, we discuss the insights that functional studies are providing on how this group of bacteria exploits their host by subverting host innate immunity and hijacking cellular processes.

Keywords: Bacterial-host interaction; Effectors; Ehrlichia; T4SS.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Dogs
Ehrlichia / pathogenicity*
Host-Pathogen Interactions*
Humans
Immune Evasion*
Rodentia
Ticks