L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles

Birgitte Hjelmeland McDonagh; Gurvinder Singh; Sjoerd Hak; Sulalit Bandyopadhyay; Ingrid Lovise Augestad; Davide Peddis; Ioanna Sandvig; Axel Sandvig; Wilhelm Robert Glomm

doi:10.1002/smll.201502545

L-DOPA-Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug-Delivery Vehicles

Small. 2016 Jan 20;12(3):301-6. doi: 10.1002/smll.201502545. Epub 2015 Nov 30.

Authors

Affiliations

¹ Uglestad Laboratory, Department of Chemical Engineering, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
² Department of Materials Science and Engineering, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
³ Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
⁴ Department of Neuroscience, Norwegian University of Science and Technology, 7491, Trondheim, Norway.
⁵ Institute of Structure and Matter, National Research Council, 00015, Monterotondo, Scalo, Italy.
⁶ John Van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, CB2 OPY, Cambridge, UK.
⁷ Division of Pharmacology and Clinical Neurosciences, Department of Neurosurgery, Umeå University, 901 87, Umeå, Sweden.
⁸ Sector for Biotechnology and Nanomedicine, SINTEF Materials and Chemistry, 7465, Trondheim, Norway.

PMID: 26619158
DOI: 10.1002/smll.201502545

Abstract

Manganese oxide nanoparticles (MONPs) are capable of time-dependent magnetic resonance imaging contrast switching as well as releasing a surface-bound drug. MONPs give T2/T2* contrast, but dissolve and release T1-active Mn(2+) and L-3,4-dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.

Keywords: MRI; contrast agents; drug delivery; l-DOPA; manganese; manganese oxide.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Coated Materials, Biocompatible / chemistry*
Contrast Media / chemistry*
Drug Delivery Systems / methods*
Levodopa / pharmacology*
Magnetic Resonance Imaging / methods*
Manganese Compounds / chemistry*
Nanoparticles / chemistry*
Nanoparticles / ultrastructure
Oxides / chemistry*
Rats
Sus scrofa
Water / chemistry

Substances

Coated Materials, Biocompatible
Contrast Media
Manganese Compounds
Oxides
Water
Levodopa
manganese oxide