Extended release of vitamins from magnetite loaded polyanionic polymeric beads

Int J Pharm. 2016 Aug 30;510(2):457-64. doi: 10.1016/j.ijpharm.2015.11.041. Epub 2015 Nov 25.

Abstract

Here we explore a novel approach of increasing the release duration of folic and ascorbic acid from magnetite entrapped into calcium-alginate beads. Synthesis and characterization of magnetite-vitamins complexes are reported. The magnetite-vitamins complexes were characterized by FT-IR, XRD, SEM, BET and DTA-TG. Also calcium-alginate magnetic beads were prepared by dripping a mixture of sodium alginate with magnetite-vitamins complexes into calcium chloride solution. Extended release profile of the two experimental models was evaluated and quantified by UV-vis.

Keywords: Ascorbic acid; Folic acid; Magnetite–vitamins; Polymeric beads.

MeSH terms

  • Alginates / chemistry
  • Ascorbic Acid / chemistry
  • Calcium / chemistry
  • Calcium Chloride / chemistry
  • Delayed-Action Preparations / chemistry*
  • Drug Carriers / chemistry
  • Ferrosoferric Oxide / chemistry*
  • Folic Acid / chemistry
  • Glucuronic Acid / chemistry
  • Hexuronic Acids / chemistry
  • Polyelectrolytes
  • Polymers / chemistry*
  • Vitamins / chemistry*

Substances

  • Alginates
  • Delayed-Action Preparations
  • Drug Carriers
  • Hexuronic Acids
  • Polyelectrolytes
  • Polymers
  • Vitamins
  • polyanions
  • Glucuronic Acid
  • Folic Acid
  • Calcium Chloride
  • Ascorbic Acid
  • Calcium
  • Ferrosoferric Oxide