Rosetta Stone of NLR Innate Immunity

Bernhard C Lechtenberg; Stefan J Riedl

doi:10.1016/j.tibs.2015.11.008

Rosetta Stone of NLR Innate Immunity

Trends Biochem Sci. 2016 Jan;41(1):6-8. doi: 10.1016/j.tibs.2015.11.008. Epub 2015 Nov 26.

Authors

Bernhard C Lechtenberg¹, Stefan J Riedl²

Affiliations

¹ NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
² NCI-designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: [email protected].

Abstract

The formation of NLR inflammasomes is a central step in the initiation of the innate immune response. Two recent publications describe the structure of the NAIP2-NLRC4 inflammasome and derive an elegant model of NLR inflammasome formation, whereby binding of the pathogen-molecule-bound NLR NAIP2 to NLRC4 leads to the activation of NLRC4 and initiation of self-propagating NLRC4 inflammasome formation.

Keywords: cryo-EM; inflammasome; inflammation; innate immunity.

Publication types

Comment

MeSH terms

Animals
Apoptosis Regulatory Proteins / chemistry*
Bacterial Proteins / chemistry*
Calcium-Binding Proteins / chemistry*
Immunity, Innate*
Inflammasomes / immunology*
Neuronal Apoptosis-Inhibitory Protein / chemistry*

Substances

Apoptosis Regulatory Proteins
Bacterial Proteins
Calcium-Binding Proteins
Inflammasomes
Neuronal Apoptosis-Inhibitory Protein

Grants and funding

R01 AA017238/AA/NIAAA NIH HHS/United States