RNF2 E3 or Not to E3: Dual Roles of RNF2 Overexpression in Melanoma

Joshua C Black; Johnathan R Whetstine

doi:10.1158/2159-8290.CD-15-1285

RNF2 E3 or Not to E3: Dual Roles of RNF2 Overexpression in Melanoma

Cancer Discov. 2015 Dec;5(12):1241-3. doi: 10.1158/2159-8290.CD-15-1285.

Authors

Joshua C Black¹, Johnathan R Whetstine²

Affiliations

¹ Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Charlestown, Massachusetts.
² Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Charlestown, Massachusetts. [email protected].

Abstract

RNF2/RING1B is amplified and overexpressed in numerous tumors and contributes to tumorigenicity; however, the biologic importance is poorly understood. Surprisingly, the role of RNF2 in tumorigenesis and invasion can be separated into catalytically independent and catalytically dependent processes.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Humans
Melanoma
Polycomb Repressive Complex 1*
Ubiquitin-Protein Ligases*

Substances

Polycomb Repressive Complex 1
Ubiquitin-Protein Ligases

Abstract

Publication types

MeSH terms

Substances

Grants and funding