Abstract
The synthesis of 9-(p-carbetoxyphenyl) guanine is reported. The assays carried out on guanine deaminase from rat and rabbit liver and pig brain show that this compound is a powerful inhibitor. The compound has a Ki = 5 micronM for the enzyme from pig brain. The use of the inhibitor for the synthesis of a specific adsorbent for guanine deaminase was studied.
MeSH terms
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Aminohydrolases / antagonists & inhibitors*
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Animals
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Binding Sites
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Brain / enzymology
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Guanine / analogs & derivatives*
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Guanine / chemical synthesis
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Guanine / pharmacology
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Guanine Deaminase / antagonists & inhibitors*
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Ligands
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Liver / enzymology
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Protein Binding
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Rats
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Sepharose
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Swine
Substances
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Ligands
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Guanine
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Sepharose
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Aminohydrolases
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Guanine Deaminase