Emergence of OXA-162 Carbapenemase- and DHA-1 AmpC Cephalosporinase-Producing Sequence Type 11 Klebsiella pneumoniae Causing Community-Onset Infection in Greece

Evangelia Voulgari; Aggeliki Poulou; Evangelia Dimitroulia; Lida Politi; Kyriaki Ranellou; Vassiliki Gennimata; Fani Markou; Spyros Pournaras; Athanassios Tsakris

doi:10.1128/AAC.01514-15

Emergence of OXA-162 Carbapenemase- and DHA-1 AmpC Cephalosporinase-Producing Sequence Type 11 Klebsiella pneumoniae Causing Community-Onset Infection in Greece

Antimicrob Agents Chemother. 2015 Dec 14;60(3):1862-4. doi: 10.1128/AAC.01514-15.

Authors

Evangelia Voulgari¹, Aggeliki Poulou², Evangelia Dimitroulia¹, Lida Politi¹, Kyriaki Ranellou¹, Vassiliki Gennimata¹, Fani Markou³, Spyros Pournaras¹, Athanassios Tsakris⁴

Affiliations

¹ Department of Microbiology, Medical School, University of Athens, Athens, Greece.
² Department of Microbiology, Medical School, University of Athens, Athens, Greece Department of Microbiology, Serres General Hospital, Serres, Greece.
³ Department of Microbiology, Serres General Hospital, Serres, Greece.
⁴ Department of Microbiology, Medical School, University of Athens, Athens, Greece [email protected].

Abstract

OXA-48-like carbapenemases have only recently emerged in Europe. OXA-162 is a rare OXA-48 variant usually coexpressed with extended-spectrum β-lactamases. Here, we report the identification of the first OXA-162 carbapenemase-producing Klebsiella pneumoniae isolates, which coexpressed an AmpC cephalosporinase (DHA-1), retrieved from a patient in Greece. They belonged to a single sequence type (ST11) and caused the first documented community-onset urinary tract infections attributable to an OXA-48-like-producing Enterobacteriaceae strain.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Bacterial Proteins / genetics*
Cephalosporinase / genetics*
Community-Acquired Infections / drug therapy
Community-Acquired Infections / microbiology
Drug Resistance, Multiple, Bacterial / genetics
Female
Greece
Humans
Klebsiella Infections / drug therapy*
Klebsiella Infections / microbiology
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / isolation & purification
Microbial Sensitivity Tests
Middle Aged
Multilocus Sequence Typing
Urinary Tract Infections / drug therapy*
Urinary Tract Infections / microbiology
beta-Lactamases / genetics*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Cephalosporinase
AmpC beta-lactamases
beta-Lactamases
beta-lactamase DHA-1, Klebsiella pneumoniae
carbapenemase
oxacillinase