Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection

Zhiyong Song; Long Liu; Xiaoyu Wang; Yongqiang Deng; Qinggong Nian; Guangchuan Wang; Shunya Zhu; Xiaofeng Li; Hangyu Zhou; Tao Jiang; Xurong Xu; Ruikang Tang; Chengfeng Qin

doi:10.1039/c5cc09252c

Intracellular delivery of biomineralized monoclonal antibodies to combat viral infection

Chem Commun (Camb). 2016 Jan 31;52(9):1879-82. doi: 10.1039/c5cc09252c.

Authors

Zhiyong Song¹, Long Liu², Xiaoyu Wang³, Yongqiang Deng⁴, Qinggong Nian⁴, Guangchuan Wang³, Shunya Zhu⁴, Xiaofeng Li⁵, Hangyu Zhou¹, Tao Jiang⁵, Xurong Xu⁶, Ruikang Tang⁶, Chengfeng Qin²

Affiliations

¹ Center for Biomaterials and Bioparthways Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China. [email protected] and Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. [email protected].
² Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. [email protected] and Anhui Medical University, Hefei 230032, P. R. China.
³ Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. [email protected] and Qiushi Academy for Advanced Studies Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.
⁴ Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. [email protected].
⁵ Department of Virology, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China. [email protected] and State Key Laboratory of Pathogen and Biosecurity, Beijing 100071, China.
⁶ Center for Biomaterials and Bioparthways Department of Chemistry, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China. [email protected] and Qiushi Academy for Advanced Studies Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China.

PMID: 26672485
DOI: 10.1039/c5cc09252c

Abstract

Conventional therapeutic monoclonal antibodies (mAbs) are invalid for intracellular viruses but by using in situ biomineralization treatment, they can be successfully delivered into cells to inhibit intracellular viral replication. This achievement significantly expands the applications of mAbs and provides a new intracellular strategy to control viral infections.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Monoclonal / administration & dosage*
Antibodies, Monoclonal / chemistry
Calcium Phosphates / chemistry*
Enzyme-Linked Immunosorbent Assay
Humans
Virus Diseases / prevention & control*

Substances

Antibodies, Monoclonal
Calcium Phosphates
calcium phosphate