Guided Bone Regeneration Using Demineralized Dentin Matrix: Long-Term Follow-Up

J Oral Maxillofac Surg. 2016 Mar;74(3):515.e1-9. doi: 10.1016/j.joms.2015.10.030. Epub 2015 Nov 10.

Abstract

Purpose: This case report reviews the long-term clinical outcomes of using demineralized dentin matrix (autogenous tooth bone graft material [AutoBT]) in 5 cases that were first reported in 2010.

Materials and methods: Cone-beam computerized tomography was used to measure the height and width of the graft to determine the change in bone area from immediately after surgery to final follow-up (average, 5 yr 5.8 months). Corticocancellous bone formation and marginal bone resorption also were evaluated histologically 3 to 6 months after grafting, which focused mainly on remodeling capacities.

Results: Decreases in buccal height and alveolar ridge width ranged from -0.4 to -3.3 mm and from -0.4 to -4.2 mm, respectively. The change in bone area ranged from -8.1 to -36.2%. Corticocancellous bone had formed and was maintained successfully except for 1 mm of buccal marginal bone resorption in 1 case followed for 6 years 7 months.

Conclusion: AutoBT, which was first reported for guided bone regeneration, showed that the corticocancellous bone that had formed had been maintained successfully with an implant after an average follow-up of 5 years. Although the number of samples was small, the results were consistent with those of other short-term follow-up studies on AutoBT.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Alveolar Process / diagnostic imaging
  • Bone Regeneration / physiology*
  • Bone Remodeling / physiology
  • Bone Resorption / physiopathology
  • Cone-Beam Computed Tomography / methods
  • Dental Implantation, Endosseous / methods
  • Dentin / physiology*
  • Female
  • Follow-Up Studies
  • Guided Tissue Regeneration / methods*
  • Humans
  • Longitudinal Studies
  • Male
  • Osteogenesis / physiology
  • Treatment Outcome

Substances

  • Demineralized Dentin Matrix