Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies

Jose R Conejo-Garcia; Melanie R Rutkowski

doi:10.1016/j.immuni.2015.11.014

Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies

Immunity. 2015 Dec 15;43(6):1037-9. doi: 10.1016/j.immuni.2015.11.014.

Authors

Jose R Conejo-Garcia¹, Melanie R Rutkowski²

Affiliations

¹ Tumor Microenvironment and Metastasis Program, Wistar Institute, Philadelphia, PA 19104, USA. Electronic address: [email protected].
² Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, VA 22908, USA.

PMID: 26682980
DOI: 10.1016/j.immuni.2015.11.014

Abstract

Commensal microorganisms influence malignant progression by altering systemic inflammation. New data from two groups (Vétizou et al., 2015; Sivan et al., 2015) indicate that the abundance of specific commensal bacterial species enhances the anti-cancer activity of immune checkpoint inhibitors.

Abstract

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