Abstract
Better prediction of in vivo drug efficacy using in vitro models should greatly improve in vivo success. Here we utilize 3D highly porous chitosan-alginate complex scaffolds to probe how various components of the glioblastoma microenvironment including extracellular matrix and stromal cells affect tumor cell stem-like state.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Alginates / chemistry*
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Cell Line, Tumor
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Chitosan / chemistry*
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Chitosan / metabolism
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Extracellular Matrix / chemistry*
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Extracellular Matrix / metabolism
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Glioblastoma / chemistry
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Glioblastoma / metabolism*
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Glucuronic Acid / chemistry
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Hexuronic Acids / chemistry
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Humans
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Neoplastic Stem Cells / chemistry
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Neoplastic Stem Cells / cytology*
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Porosity
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Tissue Engineering
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Tissue Scaffolds / chemistry*
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Tumor Microenvironment
Substances
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Alginates
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Hexuronic Acids
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Glucuronic Acid
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Chitosan