Abstract
In this paper, we investigated the oxidative profile of breast tumors in comparison with their normal adjacent breast tissue. Our study indicates that breast tumors present enhanced oxidative/nitrosative stress, with concomitant augmented antioxidant capacity when compared to the adjacent normal breast. These data indicate that breast cancers may be responsible for the induction of a prooxidant environment in the mammary gland, in association with enhanced TNF-α and nitric oxide.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Area Under Curve
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Breast / metabolism
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Breast / pathology*
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology*
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Chromatography, High Pressure Liquid
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Female
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Homocysteine / analysis
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Humans
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Lipid Peroxidation
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Malondialdehyde / analysis
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Mammary Glands, Human / metabolism
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Mammary Glands, Human / pathology*
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Middle Aged
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Nitric Oxide / analysis
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Oxidative Stress*
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Protein Carbonylation
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ROC Curve
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Tumor Necrosis Factor-alpha / analysis
Substances
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Tumor Necrosis Factor-alpha
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Homocysteine
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Nitric Oxide
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Malondialdehyde