Comprehensive analytical model for CW laser induced heat in turbid media

Opt Express. 2015 Nov 30;23(24):31069-84. doi: 10.1364/OE.23.031069.

Abstract

In this work, we present a new analytical approach to model continuous wave laser induced temperature in highly homogeneous turbid media. First, the diffusion equation is used to model light transport and a comprehensive solution is derived analytically by obtaining a special Greens' function. Next, the time-dependent bio-heat equation is used to describe the induced heat increase and propagation within the medium. The bio-heat equation is solved analytically utilizing the separation of variables technique. Our theoretical model is successfully validated using numerical simulations and experimental studies with agarose phantoms and ex-vivo chicken breast samples. The encouraging results show that our method can be implemented as a simulation tool to determine important laser parameters that govern the magnitude of temperature rise within homogenous biological tissue or organs.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Body Temperature / physiology*
  • Body Temperature / radiation effects
  • Breast / physiology*
  • Breast / radiation effects*
  • Chickens
  • Computer Simulation
  • Lasers*
  • Models, Biological*
  • Nephelometry and Turbidimetry / methods*
  • Scattering, Radiation