Complex film of chitosan and carboxymethyl cellulose nanofibers

Colloids Surf B Biointerfaces. 2016 Mar 1:139:95-9. doi: 10.1016/j.colsurfb.2015.11.056. Epub 2015 Dec 4.

Abstract

A polymer film composed of a mixture of chitosan (Ch) and carboxymethyl cellulose sodium salt (CMC) nanofibers was deposited on a glass surface. The thin film of the Ch-CMC mixture obtained was stable, and fibroblast adhesion to the film was lowest when the weight ratio of Ch to CMC was 4:6. The ζ-potential and contact angle of the mixture film indicated that a polyion complex of Ch and CMC was formed. The mechanical strength of the film composed of Ch-CMC nanofiber complexes was much higher than that of the film composed of Ch-water-soluble CMC complexes (non-nanofiber), likely because the entanglement of nanofibers was enhanced by electrostatic attractions. These results indicate that the charge-neutralized nanofiber film was highly effective in suppressing cell adhesion and therefore is a promising material for biomedical applications.

Keywords: Anti-biofouling; Carboxymethyl cellulose; Chitosan; Nanofiber film; Polyion complex.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carboxymethylcellulose Sodium / chemistry
  • Carboxymethylcellulose Sodium / pharmacology*
  • Cell Adhesion / drug effects
  • Cell Survival / drug effects
  • Chitosan / chemistry
  • Chitosan / pharmacology*
  • Mice
  • NIH 3T3 Cells
  • Nanofibers / chemistry*
  • Static Electricity
  • Surface Properties
  • Tensile Strength / drug effects

Substances

  • Chitosan
  • Carboxymethylcellulose Sodium