[Poised RNA polymerase II and master regulation in Metazoa]

K N Kashkin; E D Sverdlov

doi:10.7868/S0026898415060117

[Poised RNA polymerase II and master regulation in Metazoa]

Mol Biol (Mosk). 2015 Nov-Dec;49(6):905-14. doi: 10.7868/S0026898415060117.

[Article in Russian]

Authors

K N Kashkin¹, E D Sverdlov

Affiliation

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997 Russia.

PMID: 26710769
DOI: 10.7868/S0026898415060117

Abstract

This review is devoted to the mechanisms of transcriptional pause and poised state of RNA polymerase II. Features of poised promoters and chromatin are considered in brief. Role of regulated transcriptional pause as discrete and important stage in regulation of master genes that determine stem-cell differentiation, cell lineage and development in Metazoa is discussed. This work was supported by the Russian Science Foundation (project No. 14-50-00131).

Keywords: RNA polymerase II; chromatin; master regulation; promoter; transcription.

Publication types

English Abstract
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation, Developmental*
Humans
RNA Polymerase II / genetics
RNA Polymerase II / metabolism*
Stem Cells / cytology
Stem Cells / metabolism
Transcription, Genetic

Substances

RNA Polymerase II