Expression of DNA methylation genes in secondary progressive multiple sclerosis

Paolo Fagone; Katia Mangano; Roberto Di Marco; Chafia Touil-Boukoffa; Tinatin Chikovan; Santo Signorelli; Giuseppe A G Lombardo; Francesco Patti; Santa Mammana; Ferdinando Nicoletti

doi:10.1016/j.jneuroim.2015.11.018

Expression of DNA methylation genes in secondary progressive multiple sclerosis

J Neuroimmunol. 2016 Jan 15:290:66-9. doi: 10.1016/j.jneuroim.2015.11.018. Epub 2015 Nov 24.

Affiliations

¹ Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
² Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy.
³ Laboratory of Cellular and Molecular Biology, University of Bab-Ezzouar, Algiers, Algeria.
⁴ High Technology Medical Center, Tbilisi 1st Hospital University Clinic, Tbilisi, Georgia.
⁵ Department of Internal Medicine, Section of Anatomic Pathology, University of Catania, Milan, Italy.
⁶ Department of Neurosciences, Section of Anatomic Pathology, University of Catania, Milan, Italy.
⁷ Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy. Electronic address: [email protected].

PMID: 26711572
DOI: 10.1016/j.jneuroim.2015.11.018

Abstract

Multiple sclerosis (MS) is an immunoinflammatory disease of the central nervous system that seems to be influenced by DNA methylation. We sought to explore the expression pattern of genes involved in the control of DNA methylation in Secondary Progressive (SP) MS patients' PBMCs. We have found that SP MS is characterized by a significant upregulation of two genes belonging to the MBD family genes, MBD2 and MBD4, and by a downregulation of TDG and TET3.

Keywords: DNA methylation; Epigenetics; Multiple sclerosis.

MeSH terms

Adult
DNA Methylation / genetics*
DNA-Binding Proteins / biosynthesis*
DNA-Binding Proteins / genetics*
Female
Gene Expression Regulation
Humans
Leukocytes, Mononuclear / metabolism
Male
Middle Aged
Multiple Sclerosis, Chronic Progressive / diagnosis
Multiple Sclerosis, Chronic Progressive / genetics*
Multiple Sclerosis, Chronic Progressive / metabolism*

Substances

DNA-Binding Proteins