Epidural spinal compression as an initial presentation of Hodgkin lymphoma

Nancy Abu-Bonsrah; Akwasi Ofori Boah; C Rory Goodwin; Tatianna Larman; Genevieve M Crane; Daniel M Sciubba

doi:10.1016/j.jocn.2015.10.026

Epidural spinal compression as an initial presentation of Hodgkin lymphoma

J Clin Neurosci. 2016 Apr:26:166-8. doi: 10.1016/j.jocn.2015.10.026. Epub 2015 Dec 23.

Authors

Nancy Abu-Bonsrah¹, Akwasi Ofori Boah¹, C Rory Goodwin², Tatianna Larman³, Genevieve M Crane³, Daniel M Sciubba¹

Affiliations

¹ Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 5-185, Baltimore, MD 21287, USA.
² Department of Neurosurgery, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Meyer 5-185, Baltimore, MD 21287, USA. Electronic address: [email protected].
³ Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

PMID: 26723857
DOI: 10.1016/j.jocn.2015.10.026

Abstract

Classical Hodgkin lymphoma (CHL) commonly arises in lymph nodes and initial presentation with extranodal disease is rare. We report a patient who presented with progressively worsening back pain, lower extremity weakness and numbness concerning for a myelopathic process of uncertain etiology. MRI revealed an epidural soft tissue mass with cord displacement, for which she underwent resection. Histological analysis of the surgical specimen demonstrated CHL. Further investigation revealed an anterior mediastinal mass, consistent with spread from a more typical location.

Keywords: Epidural cord compression; Hodgkin lymphoma; Spine.

Published by Elsevier Ltd.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Female
Hodgkin Disease / complications*
Hodgkin Disease / pathology*
Humans
Magnetic Resonance Imaging / adverse effects
Spinal Cord Compression / etiology*