The epidemiology of rotavirus disease in under-five-year-old children hospitalized with acute diarrhea in central Uganda, 2012-2013

Arch Virol. 2016 Apr;161(4):999-1003. doi: 10.1007/s00705-015-2742-2. Epub 2016 Jan 2.

Abstract

A cross-sectional study was undertaken during 2012-2013 to determine the prevalence, strains and factors associated with rotavirus infection among under-5-year-old children hospitalized with acute diarrhea in Uganda. Rotaviruses were detected in 37 % (263/712) of the children. The most prevalent strains were G9P[8] (27 %, 55/204) and G12P[4] (18.6 %, 38/204). Mixed infections were detected in 22.5 % (46/204) of the children. The study suggests that consumption of raw vegetables (OR = 1.45, 95 % CI = 1.03-2.03) and family ownership of dogs (OR = 1.9, 95 % CI = 1.04-3.75) increases the risk of rotavirus infection. The study findings will be used to assess the impact of RV vaccination in Uganda.

Keywords: Food hygiene; Genotyping; Mixed infections; Reassortment; Rotavirus; Zoonotic transmission.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Male
  • Odds Ratio
  • Risk Factors
  • Rotavirus Infections / epidemiology*
  • Uganda / epidemiology