Alzheimer's disease: the amyloid hypothesis on trial

Br J Psychiatry. 2016 Jan;208(1):1-3. doi: 10.1192/bjp.bp.115.167569.

Abstract

The pathogenesis of Alzheimer's disease is complex. The amyloid hypothesis has directed research efforts for many years, but it has recently been questioned after failed drug trials. Here, we review the evidence for and against and suggest that it might be premature to abandon the amyloid hypothesis.

Publication types

  • Editorial
  • Review

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / pathology*
  • Amyloid beta-Peptides / cerebrospinal fluid*
  • Biomarkers / cerebrospinal fluid
  • Brain / diagnostic imaging*
  • Clinical Trials as Topic
  • Humans
  • Positron-Emission Tomography

Substances

  • Amyloid beta-Peptides
  • Biomarkers