Mycobacterium abscessus Complex - a Particular Challenge in the Setting of Lung Transplantation

Expert Rev Anti Infect Ther. 2016;14(3):325-33. doi: 10.1586/14787210.2016.1138856. Epub 2016 Feb 3.

Abstract

Mycobacterium abscessus complex is an emerging pathogen in lung transplant candidates and recipients. M. abscessus complex is widespread in the environment and can cause pulmonary, skin and soft tissue, and disseminated infection, particularly in lung transplant recipients. It is innately resistant to many antibiotics making it difficult to treat. Herein we describe the epidemiology, clinical manifestations, diagnosis and treatment of M. abscessus with an emphasis on lung transplant candidates and recipients. We also outline the areas where data are lacking and the areas where further research is urgently needed.

Keywords: Macrolides; Mycobacterium abscessus complex; Non tuberculous mycobacterium; diagnosis; infection; lung transplantation; treatment.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / therapeutic use
  • Disease Susceptibility
  • Drug Resistance, Bacterial
  • Humans
  • Lung Transplantation / adverse effects*
  • Mycobacterium Infections, Nontuberculous / diagnosis
  • Mycobacterium Infections, Nontuberculous / drug therapy*
  • Mycobacterium Infections, Nontuberculous / epidemiology
  • Mycobacterium Infections, Nontuberculous / pathology
  • Nontuberculous Mycobacteria / physiology

Substances

  • Anti-Bacterial Agents