Lifting the Mist on Gastric Stem Cells

Julia Varga; Florian R Greten

doi:10.1016/j.stem.2015.12.008

Lifting the Mist on Gastric Stem Cells

Cell Stem Cell. 2016 Jan 7;18(1):7-9. doi: 10.1016/j.stem.2015.12.008.

Authors

Julia Varga¹, Florian R Greten²

Affiliations

¹ Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany.
² Institute for Tumor Biology and Experimental Therapy, Georg-Speyer-Haus, Paul-Ehrlich-Strasse 42-44, 60596 Frankfurt am Main, Germany. Electronic address: [email protected].

PMID: 26748749
DOI: 10.1016/j.stem.2015.12.008

Abstract

In a recent issue of Cancer Cell, Hayakawa et al. (2015) demonstrate that Mist1(+) gastric stem cells are supported by a specialized niche composed of Cxcl12(+) endothelium and Wnt5a-producing Cxcr4(+) innate lymphoid cells. In diffuse-type gastric cancer this perivascular stem cell niche is expanded and can be exploited for cancer therapy.

Publication types

Comment

MeSH terms

Animals
Basic Helix-Loop-Helix Transcription Factors / metabolism*
Epithelial Cells / metabolism*
Gastric Mucosa / metabolism*
Humans
Male
Neoplastic Stem Cells / metabolism*
Stem Cell Niche*
Stomach Neoplasms / metabolism*
Tumor Microenvironment*

Substances

Basic Helix-Loop-Helix Transcription Factors