Abstract
The synthesis and antibacterial activity of (7S)-7-sulfur-azetidin-3-yl lincomycin derivatives are described. Modification was achieved by a simple reaction of (7R)-7-O-methanesulfonyllincomycin and the corresponding substituted azetidine-2-thiol. Several compounds first showed moderate antibacterial activity against Streptococcus pneumoniae and Streptococcus pyogenes with erm gene as lincomycin derivatives.
MeSH terms
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Anti-Bacterial Agents / chemical synthesis
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / pharmacology*
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Azetidines / chemical synthesis
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Azetidines / chemistry
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Azetidines / pharmacology*
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Genes, Bacterial
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Lincomycin / chemical synthesis
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Lincomycin / chemistry
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Lincomycin / pharmacology*
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / genetics
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Streptococcus pyogenes / drug effects
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Streptococcus pyogenes / genetics
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Structure-Activity Relationship
Substances
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Anti-Bacterial Agents
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Azetidines
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Lincomycin