Transient cyclic neutropenia following GM-CSF in a patient with chronic granulocytic leukemia transplanted with HLA-identical T cell-depleted donor bone marrow

E Gluckman; G Socie; A Yver; H Esperou; A Devergie; A Stern

Transient cyclic neutropenia following GM-CSF in a patient with chronic granulocytic leukemia transplanted with HLA-identical T cell-depleted donor bone marrow

Bone Marrow Transplant. 1989 Sep;4(5):591-2.

Authors

E Gluckman¹, G Socie, A Yver, H Esperou, A Devergie, A Stern

Affiliation

¹ Bone Marrow Transplant Unit, Hôpital Saint Louis, Paris, France.

PMID: 2676045

Abstract

Treatment with GM-CSF or G-CSF is becoming widely used in patients with chronic neutropenia, or who are aplastic following chemotherapy or autologous or allogeneic bone marrow transplantation. Recently, some authors have described a phenomenon analogous to cyclic agranulocytosis following treatment with G-CSF in a patient with chronic neutropenia. We wish to describe the same phenomenon in a patient with chronic granulocytic leukemia who received GM-CSF (Sandoz) after T cell depletion in order to accelerate hematological reconstitution.

Publication types

Case Reports

MeSH terms

Agranulocytosis / etiology*
Bone Marrow / pathology
Bone Marrow Transplantation* / pathology
Colony-Stimulating Factors / adverse effects*
Female
Granulocyte-Macrophage Colony-Stimulating Factor
Growth Substances / adverse effects*
HLA Antigens
Humans
Leukemia, Myeloid, Chronic-Phase / immunology
Leukemia, Myeloid, Chronic-Phase / surgery*
Leukemia, Myeloid, Chronic-Phase / therapy
Leukocyte Count
Lymphocyte Depletion
Middle Aged
Neutropenia / blood
Neutropenia / etiology*
Neutropenia / pathology
Periodicity
T-Lymphocytes

Substances

Colony-Stimulating Factors
Growth Substances
HLA Antigens
Granulocyte-Macrophage Colony-Stimulating Factor