Comparison between Oncotype DX test and standard prognostic criteria in estrogen receptor positive early-stage breast cancer

Einstein (Sao Paulo). 2011 Sep;9(3):354-8. doi: 10.1590/S1679-45082011AO2039.
[Article in English, Portuguese]

Abstract

Objective: To compare the prognosis estimated by standard prognostic criteria versus the prognosis estimated by the Oncotype DX.

Methods: A retrospective study was performed on 22 patients with positive estrogen receptor, early-stage breast cancer who had an Oncotype DX recurrence score available.

Results: Kappa value between Oncotype DX and standard prognostic criteria was: Adjuvant! (K = 0.091), Adjuvant! (Transbig) (K = 0.182) and National Comprehensive Cancer Network (K = 0.091). The Fisher's exact test did not show correlation between Oncotype and standard prognostic criteria.

Conclusion: Standard prognostic criteria showed no correlation with Oncotype DX.