Fluorescent MoS2 Quantum Dots: Ultrasonic Preparation, Up-Conversion and Down-Conversion Bioimaging, and Photodynamic Therapy

ACS Appl Mater Interfaces. 2016 Feb 10;8(5):3107-14. doi: 10.1021/acsami.5b10459. Epub 2016 Jan 26.

Abstract

Small size molybdenum disulfide (MoS2) quantum dots (QDs) with desired optical properties were controllably synthesized by using tetrabutylammonium-assisted ultrasonication of multilayered MoS2 powder via OH-mediated chain-like Mo-S bond cleavage mode. The tunable up-bottom approach of precise fabrication of MoS2 QDs finally enables detailed experimental investigations of their optical properties. The synthesized MoS2 QDs present good down-conversion photoluminescence behaviors and exhibit remarkable up-conversion photoluminescence for bioimaging. The mechanism of the emerging photoluminescence was investigated. Furthermore, superior (1)O2 production ability of MoS2 QDs to commercial photosensitizer PpIX was demonstrated, which has great potential application for photodynamic therapy. These early affording results of tunable synthesis of MoS2 QDs with desired photo properties can lead to application in fields of biomedical and optoelectronics.

Keywords: MoS2 quantum dots; bioimaging; photodynamic therapy (PDT); ultrasonic preparation; up-conversion fluorescence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomedical Technology*
  • Coloring Agents / chemistry
  • Coloring Agents / therapeutic use
  • Disulfides / chemical synthesis
  • Disulfides / chemistry*
  • Disulfides / therapeutic use
  • Humans
  • Luminescence
  • Molybdenum / chemistry*
  • Molybdenum / therapeutic use
  • Nanotechnology*
  • Photochemotherapy
  • Protoporphyrins / chemistry
  • Quantum Dots / chemistry*
  • Quantum Dots / therapeutic use
  • Quaternary Ammonium Compounds / chemistry

Substances

  • Coloring Agents
  • Disulfides
  • Protoporphyrins
  • Quaternary Ammonium Compounds
  • Molybdenum
  • protoporphyrin IX
  • tetrabutylammonium
  • molybdenum disulfide