Evaluating predictors of competing risk outcomes when censoring depends on time-dependent covariates, with application to safety and efficacy of HIV treatment

Stat Med. 2016 Jun 15;35(13):2183-94. doi: 10.1002/sim.6852. Epub 2016 Jan 14.

Abstract

We propose a prediction model for the cumulative incidence functions of competing risks, based on a logit link. Because of a concern about censoring potentially depending on time-varying covariates in our motivating human immunodeficiency virus (HIV) application, we describe an approach for estimating the parameters in the prediction models using inverse probability of censoring weighting under a missingness at random assumption. We then illustrate the application of this methodology to identify predictors of the competing outcomes of virologic failure, an efficacy outcome, and treatment limiting adverse event, a safety outcome, among human immunodeficiency virus-infected patients first starting antiretroviral treatment. Copyright © 2016 John Wiley & Sons, Ltd.

Keywords: HIV/AIDS; competing risks; logit link; missing at random; personalized medicine; safety and efficacy.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / therapeutic use*
  • Data Interpretation, Statistical
  • HIV Infections / drug therapy*
  • Humans
  • Models, Statistical*
  • Probability
  • Risk Assessment
  • Time Factors
  • Treatment Failure
  • Treatment Outcome

Substances

  • Anti-HIV Agents