In vitro antimicrobial susceptibility of Alloscardovia omnicolens and molecular mechanisms of acquired resistance

Diagn Microbiol Infect Dis. 2016 Mar;84(3):227-9. doi: 10.1016/j.diagmicrobio.2015.08.009. Epub 2015 Aug 20.

Abstract

All the 31 isolates of Alloscardovia omnicolens exhibited low MICs for β-lactams, glycopeptides, linezolid, tetracyclines, and cotrimoxazole. One strain showed MICs ≥256μg/mL for both erythromycin and clindamycin with a single point mutation in 23S rRNA. One strain likely had acquired fluoroquinolone resistance associated with a unique mutation in ParC.

Keywords: 23S rRNA mutation; A. omnicolens; Fluoroquinolone resistance; Macrolide resistance; QRDR; parC mutation.

MeSH terms

  • Actinobacteria / drug effects*
  • Actinobacteria / genetics*
  • Actinobacteria / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Base Sequence
  • Drug Resistance, Bacterial*
  • Gram-Positive Bacterial Infections / diagnosis
  • Gram-Positive Bacterial Infections / microbiology
  • Humans
  • Microbial Sensitivity Tests*
  • Molecular Sequence Data
  • Mutation
  • RNA, Ribosomal, 23S / chemistry
  • RNA, Ribosomal, 23S / genetics
  • Sequence Alignment

Substances

  • Anti-Bacterial Agents
  • RNA, Ribosomal, 23S