Tissue-Specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans

Neeraj K Sharma; Satria P Sajuthi; Jeff W Chou; Jorge Calles-Escandon; Jamehl Demons; Samantha Rogers; Lijun Ma; Nicholette D Palmer; David R McWilliams; John Beal; Mary E Comeau; Kristina Cherry; Gregory A Hawkins; Lata Menon; Ethel Kouba; Donna Davis; Marcie Burris; Sara J Byerly; Linda Easter; Donald W Bowden; Barry I Freedman; Carl D Langefeld; Swapan K Das

doi:10.1210/jc.2015-3336

Tissue-Specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans

J Clin Endocrinol Metab. 2016 Apr;101(4):1455-68. doi: 10.1210/jc.2015-3336. Epub 2016 Jan 20.

Authors

Neeraj K Sharma¹, Satria P Sajuthi¹, Jeff W Chou¹, Jorge Calles-Escandon¹, Jamehl Demons¹, Samantha Rogers¹, Lijun Ma¹, Nicholette D Palmer¹, David R McWilliams¹, John Beal¹, Mary E Comeau¹, Kristina Cherry¹, Gregory A Hawkins¹, Lata Menon¹, Ethel Kouba¹, Donna Davis¹, Marcie Burris¹, Sara J Byerly¹, Linda Easter¹, Donald W Bowden¹, Barry I Freedman¹, Carl D Langefeld¹, Swapan K Das¹

Affiliation

¹ Department of Internal Medicine (N.K.S., J.C.-E., J.D., S.R., L.Ma., K.C., L.Me., E.K., D.D., B.I.F., S.K.D.), Center for Public Health Genomics (N.K.S., S.P.S., J.W.C., L.Ma., N.D.P., D.R.M., M.C., G.A.H., B.I.F., C.D.L., S.K.D.), Department of Biostatistical Sciences, Division of Public Health Sciences (S.P.S., J.W.C., D.R.M., J.B., M.C., C.D.L.), Department of Biochemistry (N.D.P., D.W.B.), Center for Diabetes Research and Center for Genomics and Personalized Medicine Research (N.D.P., G.A.H., D.W.B., B.I.F.), and Clinical Research Unit, Biomedical Research Services and Administration (M.B., S.J.B., L.E.), Wake Forest School of Medicine, Winston-Salem, North Carolina 27157.

Abstract

Integrative multiomics analyses of adipose and muscle tissue transcripts, S, and genotypes revealed novel genetic regulatory mechanisms of insulin resistance in African Americans.

Publication types

Comparative Study

MeSH terms

Adipose Tissue / metabolism*
Adolescent
Adult
Biomarkers / metabolism*
Black or African American / genetics*
Cross-Sectional Studies
Female
Gene Expression Regulation*
Glucose Tolerance Test
High-Throughput Nucleotide Sequencing
Humans
Insulin Resistance / genetics*
Male
Middle Aged
Muscle, Skeletal / metabolism*
White People / genetics
Young Adult

Substances

Biomarkers

Grants and funding

R01 DK090111/DK/NIDDK NIH HHS/United States