Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging

D E Korenchan; R R Flavell; C Baligand; R Sriram; K Neumann; S Sukumar; H VanBrocklin; D B Vigneron; D M Wilson; J Kurhanewicz

doi:10.1039/c5cc09724j

Dynamic nuclear polarization of biocompatible (13)C-enriched carbonates for in vivo pH imaging

Chem Commun (Camb). 2016 Feb 18;52(14):3030-3. doi: 10.1039/c5cc09724j.

Authors

Affiliations

¹ UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley and University of California, San Francisco, California, USA. [email protected] and Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. [email protected].
² Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA. [email protected].

Abstract

A hyperpolarization technique using carbonate precursors of biocompatible molecules was found to yield high concentrations of hyperpolarized (13)C bicarbonate in solution. This approach enabled large signal gains for low-toxicity hyperpolarized (13)C pH imaging in a phantom and in vivo in a murine model of prostate cancer.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Biocompatible Materials*
Carbon Isotopes / chemistry*
Carbon-13 Magnetic Resonance Spectroscopy
Hydrogen-Ion Concentration*

Substances

Biocompatible Materials
Carbon Isotopes

Abstract

Publication types

MeSH terms

Substances

Grants and funding