The cytokine-serum amyloid A-chemokine network

Mieke De Buck; Mieke Gouwy; Ji Ming Wang; Jacques Van Snick; Paul Proost; Sofie Struyf; Jo Van Damme

doi:10.1016/j.cytogfr.2015.12.010

The cytokine-serum amyloid A-chemokine network

Cytokine Growth Factor Rev. 2016 Aug:30:55-69. doi: 10.1016/j.cytogfr.2015.12.010. Epub 2015 Dec 28.

Authors

Mieke De Buck¹, Mieke Gouwy², Ji Ming Wang³, Jacques Van Snick⁴, Paul Proost⁵, Sofie Struyf⁶, Jo Van Damme⁷

Affiliations

¹ KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, Minderbroedersstraat 10, 3000 Leuven, Belgium. Electronic address: [email protected].
² KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, Minderbroedersstraat 10, 3000 Leuven, Belgium. Electronic address: [email protected].
³ Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA. Electronic address: [email protected].
⁴ Ludwig Cancer Research, Brussels Branch, Brussels, Belgium; e Duve Institute, Université Catholique de Louvain, Brussels, Belgium. Electronic address: [email protected].
⁵ KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, Minderbroedersstraat 10, 3000 Leuven, Belgium. Electronic address: [email protected].
⁶ KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, Minderbroedersstraat 10, 3000 Leuven, Belgium. Electronic address: [email protected].
⁷ KU Leuven, University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Molecular Immunology, Minderbroedersstraat 10, 3000 Leuven, Belgium. Electronic address: [email protected].

Abstract

Levels of serum amyloid A (SAA), a major acute phase protein in humans, are increased up to 1000-fold upon infection, trauma, cancer or other inflammatory events. However, the exact role of SAA in host defense is yet not fully understood. Several pro- and anti-inflammatory properties have been ascribed to SAA. Here, the regulated production of SAA by cytokines and glucocorticoids is discussed first. Secondly, the cytokine and chemokine inducing capacity of SAA and its receptor usage are reviewed. Thirdly, the direct (via FPR2) and indirect (via TLR2) chemotactic effects of SAA and its synergy with chemokines are unraveled. Altogether, a complex cytokine-SAA-chemokine network is established, in which SAA plays a key role in regulating the inflammatory response.

Keywords: Chemotaxis; Cytokines; FPR2; SAA; TLR2.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cytokines / metabolism*
Humans
Liver / metabolism
Serum Amyloid A Protein / metabolism*
Signal Transduction

Substances

Cytokines
Serum Amyloid A Protein

Grants and funding

Z01 BC010015/ImNIH/Intramural NIH HHS/United States