Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency

Reza Yazdani; Maryam Fatholahi; Mazdak Ganjalikhani-Hakemi; Hassan Abolhassani; Gholamreza Azizi; Kabir Magaji Hamid; Nima Rezaei; Asghar Aghamohammadi

doi:10.1016/j.molimm.2015.12.016

Role of apoptosis in common variable immunodeficiency and selective immunoglobulin A deficiency

Mol Immunol. 2016 Mar:71:1-9. doi: 10.1016/j.molimm.2015.12.016. Epub 2016 Jan 12.

Authors

Reza Yazdani¹, Maryam Fatholahi², Mazdak Ganjalikhani-Hakemi³, Hassan Abolhassani⁴, Gholamreza Azizi⁵, Kabir Magaji Hamid⁶, Nima Rezaei⁷, Asghar Aghamohammadi⁸

Affiliations

¹ Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran; Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran.
² Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran.
³ Department of Immunology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
⁴ Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran; Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institutet at the Karolinska University Hospital Huddinge, Stockholm, Sweden.
⁵ Imam Hassan Mojtaba Hospital, Alborz University of Medical Sciences, Karaj, Iran.
⁶ Immunology Department, School of Public Health, Tehran University of Medical Sciences-International Campus (TUMS-IC), Tehran, Iran; Immunology Department, Faculty of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
⁷ Department of Immunology, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
⁸ Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran. Electronic address: [email protected].

PMID: 26795881
DOI: 10.1016/j.molimm.2015.12.016

Abstract

Common variable immunodeficiency (CVID) and selective IgA deficiency (SIgAD) are the most common primary immunodeficiencies in human. Both diseases share clinical manifestation and molecular defects. Increased apoptosis may be one of the mechanisms involved in the pathogenesis of CVID and SIgAD. Elevated apoptosis in this disorder leads to defective long-term survival of B-cells, reduced antibody production, decreased lymphocyte proliferation and defective cytokine secretion. For the first time, we reviewed the role of apoptosis in CVID and SIgAD.

Keywords: Apoptosis; Common variable immunodeficiency; IgA deficiency.

Publication types

Review

MeSH terms

Apoptosis / immunology*
B-Lymphocyte Subsets / immunology
B-Lymphocyte Subsets / pathology*
Common Variable Immunodeficiency / immunology*
Common Variable Immunodeficiency / pathology
Humans
IgA Deficiency / immunology*
IgA Deficiency / pathology
T-Lymphocyte Subsets / immunology
T-Lymphocyte Subsets / pathology*