Stop and Think about Basal Ganglia Functional Organization: The Pallido-Striatal "Stop" Route

Marc Deffains; Liliya Iskhakova; Hagai Bergman

doi:10.1016/j.neuron.2016.01.003

Stop and Think about Basal Ganglia Functional Organization: The Pallido-Striatal "Stop" Route

Neuron. 2016 Jan 20;89(2):237-9. doi: 10.1016/j.neuron.2016.01.003.

Authors

Marc Deffains¹, Liliya Iskhakova¹, Hagai Bergman²

Affiliations

¹ Department of Medical Neurobiology, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, 91904, Israel.
² Department of Medical Neurobiology, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, 91120, Israel; The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University, Jerusalem, 91904, Israel; Department of Neurosurgery, Hadassah Medical Center, Jerusalem, 12000, Israel. Electronic address: [email protected].

PMID: 26796685
DOI: 10.1016/j.neuron.2016.01.003

Abstract

The "arkypallidal" neurons of the globus pallidus (external segment) emit feedback GABAergic projections to the striatum. In this issue of Neuron, Mallet et al. (2016) show that "arkypallidal" neurons provide a Stop signal, suppressing the development of Go-related striatal activity.

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MeSH terms

Animals
Corpus Striatum / physiology*
Globus Pallidus / physiology*
Impulsive Behavior / physiology*
Neural Inhibition / physiology*
Neurons / physiology*
Sleep Stages / physiology*