Chasing One-Carbon Units to Understand the Role of Serine in Epigenetics

Seth J Parker; Christian M Metallo

doi:10.1016/j.molcel.2016.01.006

Chasing One-Carbon Units to Understand the Role of Serine in Epigenetics

Mol Cell. 2016 Jan 21;61(2):185-6. doi: 10.1016/j.molcel.2016.01.006.

Authors

Seth J Parker¹, Christian M Metallo²

Affiliations

¹ Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA.
² Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA; Moores Cancer Center, University of California, San Diego, La Jolla, California 92093, USA. Electronic address: [email protected].

PMID: 26799763
DOI: 10.1016/j.molcel.2016.01.006

Abstract

In this issue of Molecular Cell, Maddocks et al. (2016) use stable isotope tracing, mass spectrometry, and nutrient modulation in cancer cells to highlight the role of serine in supporting methylation through maintenance of nucleotide levels.

Publication types

Comment

MeSH terms

Adenosine Triphosphate / biosynthesis*
DNA Methylation*
Humans
Methionine / metabolism*
Neoplasms / metabolism*
Serine / metabolism*

Substances

Serine
Adenosine Triphosphate
Methionine