Abstract
Recent advances in massively parallel sequencing technologies have provided a detailed picture of the mutational landscape in CLL and underscored the vast degree of interpatient and intratumor heterogeneities. These studies have led to the characterization of novel putative driver genes and recurrently affected biological pathways, and to the modeling of CLL clonal evolution. We herein review selected aspects including recent advances in the biology of CLL and present cellular and biological processes involved in the development of CLL and potentially other mature B-cell lymphoproliferative neoplasms.
© 2016 Wiley Periodicals, Inc.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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B-Lymphocytes / metabolism
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B-Lymphocytes / pathology
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Cell Transformation, Neoplastic / genetics
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Chromosome Aberrations
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Clone Cells
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DNA Methylation
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Disease Progression
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Evolution, Molecular
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Forecasting
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Genes, Immunoglobulin
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Genes, Neoplasm
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Genetic Heterogeneity
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Genomics*
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Histone Code
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Humans
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Leukemia, Experimental / genetics
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Leukemia, Lymphocytic, Chronic, B-Cell / pathology
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Lymphoproliferative Disorders / genetics
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Lymphoproliferative Disorders / pathology
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Mice
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Models, Genetic
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Mutation*
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology
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Paraproteinemias / genetics
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Paraproteinemias / pathology
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Signal Transduction / genetics