Rabies Virus CVS-N2c(ΔG) Strain Enhances Retrograde Synaptic Transfer and Neuronal Viability

Neuron. 2016 Feb 17;89(4):711-24. doi: 10.1016/j.neuron.2016.01.004. Epub 2016 Jan 21.

Abstract

Virally based transsynaptic tracing technologies are powerful experimental tools for neuronal circuit mapping. The glycoprotein-deletion variant of the SAD-B19 vaccine strain rabies virus (RABV) has been the reagent of choice in monosynaptic tracing, since it permits the mapping of synaptic inputs to genetically marked neurons. Since its introduction, new helper viruses and reagents that facilitate complementation have enhanced the efficiency of SAD-B19(ΔG) transsynaptic transfer, but there has been little focus on improvements to the core RABV strain. Here we generate a new deletion mutant strain, CVS-N2c(ΔG), and examine its neuronal toxicity and efficiency in directing retrograde transsynaptic transfer. We find that by comparison with SAD-B19(ΔG), the CVS-N2c(ΔG) strain exhibits a reduction in neuronal toxicity and a marked enhancement in transsynaptic neuronal transfer. We conclude that the CVS-N2c(ΔG) strain provides a more effective means of mapping neuronal circuitry and of monitoring and manipulating neuronal activity in vivo in the mammalian CNS.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials / genetics
  • Animals
  • Cells, Cultured
  • Electric Stimulation
  • Glycoproteins / deficiency*
  • Glycoproteins / genetics
  • Humans
  • Luminescent Proteins / genetics
  • Luminescent Proteins / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Nerve Net / physiology*
  • Neural Pathways / physiology
  • Neuroblastoma / pathology
  • Neurons / physiology*
  • Neurons / virology
  • Optogenetics
  • Protein Transport
  • Rabies virus / physiology*
  • Viral Envelope Proteins

Substances

  • Glycoproteins
  • Luminescent Proteins
  • Viral Envelope Proteins
  • fluorescent protein 583