Primary Biliary Cirrhosis Overlapping with Autoimmune Hepatitis in an HIV-Infected Patient on Antiretroviral Therapy

Margaret Caplan; Apurva Trivedi; Mary McLaughlin; Annick Hebou; David E Kleiner; Theo Heller; Caryn G Morse

doi:10.5455/jihp.20130624104921

Primary Biliary Cirrhosis Overlapping with Autoimmune Hepatitis in an HIV-Infected Patient on Antiretroviral Therapy

J Interdiscip Histopathol. 2013;1(5):270-273. doi: 10.5455/jihp.20130624104921. Epub 2013 Jun 30.

Authors

Margaret Caplan¹, Apurva Trivedi², Mary McLaughlin³, Annick Hebou⁴, David E Kleiner⁵, Theo Heller², Caryn G Morse⁶

Affiliations

¹ Clinical Research Directorate/CMRP, SAIC-Frederick, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
² Liver Diseases Branch, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
³ Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
⁴ Carl Vogel Center, Washington, DC; USA.
⁵ Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, MD, USA.
⁶ Critical Care Medicine Department, NIH Clinical Center, Bethesda, MD, USA.

Abstract

Liver disease in HIV-infected patients is complex and multifactorial. Drug toxicity and infections are common causes of elevations in liver-associated enzymes. Immune reconstitution and unmasking of autoimmune disease may also play a role, particularly in the era of effective combination antiretroviral therapy. In this case report, we describe the first reported biopsy-confirmed case of autoimmune hepatitis and primary biliary cirrhosis overlap syndrome presenting in an HIV-infected patient following initiation of antiretroviral therapy.

Keywords: HIV; autoimmune hepatitis; immune reconstitution; liver biopsy; overlap syndrome.

Abstract

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